منابع مشابه
New developments in anti-HIV chemotherapy.
Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs): i.e. zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine, tenofovir (PMPA) disoproxil fumarate; (ii) non-nucleoside reverse transcrip...
متن کاملRecent developments in the chemotherapy of HIV infect ions
The HIV replicative cycle reveals several virus-specific events that could function as targets for chemotherapeutic intervention. The compounds that are presently available as anti-HIV drugs are targeted at either the substrate binding site of the reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine) or a non-substrate binding site of the reverse transcriptase (nevi...
متن کاملNew developments in chemotherapy for patients with advanced pancreatic cancer.
Alleviation of tumor-related symptoms may be a more appropriate basis for judging drug efficacy in pancreatic cancer than is tumor shrinkage. Clinical benefit response (CBR), a new way to assess clinical efficacy based on marked, sustained improvement in pain intensity, analgesic consumption, and performance status, was used to evaluate a new chemotherapeutic agent, gemcitabine (2',2'-difluorod...
متن کاملHyperthermia and hypoxia: new developments in anticancer chemotherapy.
It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5--43 degrees C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to mos...
متن کاملSome New Developments in Small Area Estimation
Small area estimation has received a lot of attention in recent years due to growing demand for reliable small area statistics. Traditional area-specific estimators may not provide adequate precision because sample sizes in small areas are seldom large enough. This makes it necessary to employ indirect estimators based on linking models. Basic area level and unit level models have been extensiv...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2001
ISSN: 0929-8673
DOI: 10.2174/0929867013371842